Details are limited, but police said the woman was riding in a vehicle with several people when a black Toyota SUV pulled alongside them in the 8600 block of Glenvista and started shooting.
The SUV then sped away.
The driver of the car carrying the victim pulled into a gas station in the 8100 block of River Drive near the Gulf Freeway and called 911.
The woman, who police said was in her 30s, was pronounced dead at the scene by first responders. Her name hasn't been released.
No one else in the vehicle was hurt.
The occupants told police they have no idea why someone fired at them.
At this time, there is no known suspect or motive in the shooting.
Anyone with information in this case is urged to contact the HPD Homicide Division at 713-308-3600 or Crime Stoppers at 713-222-TIPS.
Here's the Monday night update police provided at the scene: