The incident happened around 10 p.m. Tuesday at the intersection of 4th Street and Purdy.
Police said they responded to a call of shots fired. When they arrived on the scene, they discovered multiple victims shot.
Police did not release any information as to exactly how many people were shot or their conditions.
The motive for the shooting or what led up to the incident is unknown at this time.
A suspect was still at large Wednesday morning, according to police.
Police say they have identified a person of interest in the shooting.
Anyone with information on the shooting is asked to contact Brookshire police directly at (281) 375-5000.