Unless the shuttle’s Thursday landing is delayed, there will be only 1 opportunity to see it and the International Space Station zipping through the skies over the Houston area. If you really want to see it, you'll need to set the alarm clock early. Rabid sky watchers should train their eyes toward the southeast Wednesday morning at 5:43 AM. Hurry, the fast but silent moving specs will only appear for a scant 3 minutes. Both spacecraft will appear very low to the horizon. Hold your fist out so that the bottom of the fist is lined up with the horizon. The shuttle and the ISS should appear slightly above the top of the fist.
I've seen both before under better circumstances and they are quite a sight. Remember, you won't hear anything, like the sound of an airplane and the light will be a steady and bright spot. One issue could be cloud cover if expected Tuesday rains leave behind clouds in this very humid atmosphere over our area. I still say it's worth an attempted look as the final chapter of this part of NASA's space exploration comes to a close.
If, for some reason, the shuttle doesn't land Thursday, there will be another chance Friday at 5:15 AM and again Saturday at 5:49 AM. Right now, the forecast Thursday morning is for clear skies so set those alarm clocks for early Wednesday; good luck and happy viewing!