An 18-wheeler flipped on its side and caught fire at the interchange of the Southwest Freeway and Highway 288 on Saturday evening.
The Houston Police Department said the incident happened around 7:30 p.m. and fuel spilled across the highway.
Firefighters managed to put out the fire before it spread to a nearby apartment complex.
No injuries were reported.
All southbound mainlanes of IH-69 Southwest at Highway 288 are shut down.